About NetworkAnalyzer

NetworkAnalyzer is a flash-based online software environment which enables biologists to easily visualize and analyze high-throughput experimental data in the context of complex protein network hypotheses, peform quantitative simulations, collaborate with colleagues, and publish experiments and analysis.

1 network biology 2 visualization & analysis 3 collaboration & open access

NetworkAnalyzer Gallery

Follicular Lymphoma

Description
B cell signaling network in follicular lymphoma

Contributed By
Jonathan Karr, Harendra Guturu, Ed Chen, 3/30/2009

References

  • Jonathan M. Irish, Debra K. Czerwinski, Garry P. Nolan, and Ronald Levy (2006). Altered B - cell receptor signaling kinetics distinguish human follicular lymphoma B cells from tumor - infiltrating nonmalignant B cells. Blood. 108 (9): 3135-42. [PubMed]

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NF-κB

Description
NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that acts as a transcription factor. NF-kB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-kB has been linked to cancer.

Contributed By
Jonathan Karr, 3/30/2009

References

  • TD Gilmore (2006). Introduction to NF-κB: players, pathways, perspectives. Oncogene. 25 (51): 6680-4. [PubMed]
  • AR Brasier (2006). The NF-κB regulatory network. Cardiovasc. Toxicol. 6 (2): 111-30. [PubMed]
  • ND Perkins (2007). Integrating cell-signalling pathways with NF-κB and IKK function. Nat. Rev. Mol. Cell Biol. 8 (1): 49-62. [PubMed]

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TCR Signaling

Description
The adaptive phase of the immune response begins with engagement on CD4+ helper T cells of the T cell antigen receptor (TCR) by its ligand, a small foreign peptide bound to a cell surface protein of the class II major histocompatibility complex (peptide-MHC) expressed on an antigen-presenting cell. This engagement initiates a series of biochemical events that can differentially signal the naive T cell to: 1) enter into a pathway leading to generation of effector T cells with the onset of rapid proliferation and production of effector cytokines; 2) enter into a state of antigenic non-responsiveness known as anergy; or 3) die by apoptosis.

Contributed By
Jonathan Karr, 3/30/2009

References

  • Yanping Huang and Ronald L. Wange (2004). T Cell Receptor Signaling: Beyond Complex Complexes. J. Biol. Chem. 279 (28): 28827-28830. [PubMed]

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